Publications

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2019


A high resolution LC-MS targeted method for the concomitant analysis of 11 contraceptive progestins and 4 steroids.
Laszlo CF, Paz Montoya J, Shamseddin M, De Martino F, Beguin A, Nellen R, Bruce SJ, Moniatte M, Henry H, Brisken C
J Pharm Biomed Anal. 2019 Jul 25;175:112756. doi: 10.1016/j.jpba.2019.07.004. [Epub ahead of print]

Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles.
Cianciaruso C, Beltraminelli T, Duval F, Nassiri S, Hamelin R, Mozes A, Gallart-Ayala H, Ceada Torres G, Torchia B, Ries CH, Ivanisevic J, De Palma M
Cell Rep. 2019 Jun 4;27(10):3062-3080.e11. doi: 10.1016/j.celrep.2019.05.008.

Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice.
Moreau D, Vacca F, Vossio S, Scott C, Colaco A, Paz Montoya J, Ferguson C, Damme M, Moniatte M, Parton RG, Platt FM, Gruenberg J.
EMBO Rep. 2019 May 22. pii: e47055. doi: 10.15252/embr.201847055. [Epub ahead of print]

Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid – method comparison and round robin study.
Mollenhauer B, Bowman FD, Drake D, Duong J, Blennow K, El-Agnaf O, Shaw LM, Masucci J, Taylor P, Umek RM, Dunty JM, Smith CL, Stoops E, Vanderstichele H, Schmid AW, Moniatte M, Zhang J, Kruse N, Lashuel HA, Teunissen C, Schubert T, Dave KD, Hutten SJ, Zetterberg H
J Neurochem. 2019 Apr;149(1):126-138. doi: 10.1111/jnc.14569. Epub 2018 Nov 13.

The Exchangeable Apolipoprotein Nplp2 Sustains Lipid Flow and Heat Acclimation in Drosophila.
Rommelaere S, Boquete JP, Piton J, Kondo S, Lemaitre B.
Cell Rep. 2019 Apr 16;27(3):886-899.e6. doi: 10.1016/j.celrep.2019.03.074.

Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients.
Broggi MAS, Maillat L, Clement CC, Bordry N, Corthésy P, Auger A, Matter M, Hamelin R, Potin L, Demurtas D, Romano E, Harari A, Speiser DE, Santambrogio L, Swartz MA
J Exp Med. 2019 Apr 11. pii: jem.20181618. doi: 10.1084/jem.20181618. [Epub ahead of print]

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging.
D’Amico D, Mottis A, Potenza F, Sorrentino V, Li H, Romani M, Lemos V, Schoonjans K, Zamboni N, Knott G, Schneider BL, Auwerx J.
Mol Cell. 2019 Feb 21;73(4):775-787.e10. doi: 10.1016/j.molcel.2018.11.034. Epub 2019 Jan 11.

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models.
Keklikoglou I, Cianciaruso C, Güç E, Squadrito ML, Spring LM, Tazzyman S, Lambein L, Poissonnier A, Ferraro GB, Baer C, Cassará A, Guichard A, Iruela-Arispe ML, Lewis CE, Coussens LM, Bardia A, Jain RK, Pollard JW, De Palma M.
Nat Cell Biol. 2019 Feb;21(2):190-202. doi: 10.1038/s41556-018-0256-3. Epub 2018 Dec 31.

Cyclodextrin triggers MCOLN1-dependent endo-lysosome secretion in Niemann-Pick type C cells.
Vacca F, Vossio S, Mercier V, Moreau D, Johnson S, Scott CC, Paz Montoya J, Moniatte M, Gruenberg J.
J Lipid Res. 2019 Feb 1. pii: jlr.M089979. doi: 10.1194/jlr.M089979. [Epub ahead of print]

Analysis of the S. pombe Meiotic Proteome Reveals a Switch from Anabolic to Catabolic Processes and Extensive Post-transcriptional Regulation.
Krapp A, Hamelin R , Armand F , Chiappe D, Krapp L, Cano E, Moniatte M, Simanis V.
Cell Rep. 2019 Jan 22;26(4):1044-1058.e5. doi: 10.1016/j.celrep.2018.12.075.

Anthrax toxin requires ZDHHC5-mediated palmitoylation of its surface-processing host enzymes.
Sergeeva OA, van der Goot FG
Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1279-1288. doi: 10.1073/pnas.1812588116. Epub 2019 Jan 4.

2018


EspL is essential for virulence and stabilizes EspE, EspF and EspH levels in Mycobacterium tuberculosis.
Sala C, Odermatt NT, Soler-Arnedo P, Gülen MF, von Schultz S, Benjak A, Cole ST.
PLoS Pathog. 2018 Dec 20;14(12):e1007491. doi: 10.1371/journal.ppat.1007491. eCollection 2018 Dec.

Beyond Unpredictability: The Importance of Reproducibility in Understanding the Protein Corona of Nanoparticles.
Galmarini S, Hanusch U, Giraud M, Cayla N, Chiappe D, von Moos N, Hofmann H, Maurizi L.
Bioconjug Chem. 2018 Sep 19. doi: 10.1021/acs.bioconjchem.8b00554. [Epub ahead of print]

Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid – method comparison and round robin study.
Mollenhauer B, DuBois BF, Drake D, Duong J, Blennow K, El-Agnaf O, Shaw LM, Masucci J, Taylor P, Umek RM, Dunty IM, Smith CL, Stoops E, Vanderstichele H, Schmid AW, Moniatte M, Zhang J, Kruse N, Lashuel HA, Teunissen C, Schubert T, Dave KD, Hutten SJ, Zetterberg H
J Neurochem. 2018 Aug 20. doi: 10.1111/jnc.14569. [Epub ahead of print]

The Membrane-Bound C Subunit of Reductive Dehalogenases: Topology Analysis and Reconstitution of the FMN-Binding Domain of PceC.
Buttet GF, Willemin MS, Hamelin R, Rupakula A, Maillard J.
Front Microbiol. 2018 Apr 24;9:755. doi: 10.3389/fmicb.2018.00755. eCollection 2018.

EVIR: chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens.
Squadrito ML, Cianciaruso C, Hansen SK, De Palma M.
Nat Methods. 2018 Jan 22. doi: 10.1038/nmeth.4579. [Epub ahead of print]

2017


Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity.
Sorrentino V, Romani M, Mouchiroud L, Beck JS, Zhang H, D’Amico D, Moullan N, Potenza F, Schmid AW , Rietsch S, Counts SE, Auwerx J.
Nature. 2017 Dec 14;552(7684):187-193. doi: 10.1038/nature25143. Epub 2017 Dec 6.

Lipidomics reveals diurnal lipid oscillations in human skeletal muscle persisting in cellular myotubes cultured in vitro.
Loizides-Mangold U, Perrin L, Vandereycken B, Betts JA, Walhin JP, Templeman I, Chanon S, Weger BD, Durand C, Robert M, Paz Montoya J , Moniatte M , Karagounis LG, Johnston JD, Gachon F, Lefai E, Riezman H, Dibner C.
Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8565-E8574. doi: 10.1073/pnas.1705821114. Epub 2017 Sep 25.

Lysine acetylation stoichiometry and proteomics analyses reveal pathways regulated by sirtuin 1 in human cells.
Gil J, Ramírez-Torres A, Chiappe D , Luna-Peñaloza J, Fernandez-Reyes FC, Arcos-Encarnación B, Contreras S, Encarnación-Guevara S.
J Biol Chem. 2017 Sep 11. pii: jbc.M117.784546. doi: 10.1074/jbc.M117.784546. [Epub ahead of print]

A user’s guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations.
Mollenhauer B, Batrla R, El-Agnaf O, Galasko DR, Lashuel HA, Merchant KM, Shaw LM, Selkoe DJ, Umek R, Vanderstichele H, Zetterberg H, Zhang J, Caspell-Garcia C, Coffey C, Hutten SJ, Frasier M, Taylor P; Investigating Synuclein Consortium of the Michael J. Fox Foundation for Parkinson’s Research.
Mov Disord. 2017 Aug;32(8):1117-1130. doi: 10.1002/mds.27090. Epub 2017 Jul 22.

Protein Corona: Impact of Lymph Versus Blood in a Complex In Vitro Environment.
Bonvin D, Aschauer U, Alexander DTL, Chiappe D , Moniatte M , Hofmann H, Mionić Ebersold M.
Small. 2017 Aug;13(29). doi: 10.1002/smll.201700409. Epub 2017 Jun 5.

Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis.
Hamel V, Steib E, Hamelin R , Armand F , Borgers S, Flückiger I, Busso C, Olieric N, Sorzano COS, Steinmetz MO, Guichard P, Gönczy P
Curr Biol. 2017 Jul 29. pii: S0960-9822(17)30869-2. doi: 10.1016/j.cub.2017.07.011. [Epub ahead of print]

The T-cell leukemia associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling.
Girardi T, Vereecke S, Sulima SO, Khan Y, Fancello L, Briggs JW, Schwab C, de Beeck JO, Verbeeck J, Royaert J, Geerdens E, Vicente C, Bornschein S, Harrison CJ, Meijerink JP, Cools J, Dinman JD, Kampen KR, De Keersmaecker K.
Leukemia. 2017 Jul 24. doi: 10.1038/leu.2017.225. [Epub ahead of print]

Methods of protein corona isolation for magnetic nanoparticles.
Bonvin D, Chiappe D , Moniatte M , Hofmann H, Mionić Ebersold M.
Analyst. 2017 Jul 11. doi: 10.1039/c7an00646b. [Epub ahead of print]

Sexual dimorphism in hepatic lipids is associated with the evolution of metabolic status in mice
Soares AF, Paz-Montoya J , Lei H, Moniatte M , Gruetter R
NMR Biomed. 2017 Oct;30(10). doi: 10.1002/nbm.3761. Epub 2017 Jun 29.

CMG2/ANTXR2 regulates extracellular collagen VI which accumulates in hyaline fibromatosis syndrome
Bürgi J, Kunz B, Abrami L, Deuquet J, Piersigilli A, Scholl-Bürgi S, Lausch E, Unger S, Superti-Furga A, Bonaldo P, Van der Goot FG
Nat Communications 2017 Jun 12;8:15861 doi:10.1038/ncomms15861

Differential signaling networks of Bcr-Abl p210 and p190 kinases in leukemia cells defined by functional proteomics.
Reckel S, Hamelin R , Georgeon S, Armand F , Jolliet Q , Chiappe D , Moniatte M , Hantschel O.
Leukemia. 2017 Feb 24. doi: 10.1038/leu.2017.36. [Epub ahead of print]

EspC forms a filamentous structure in the cell envelope of Mycobacterium tuberculosis and impacts ESX-1 secretion.
Lou Y, Rybniker J, Sala C, Cole ST.
Mol Microbiol. 2017 Jan;103(1):26-38. doi: 10.1111/mmi.13575. Epub 2016 Nov 25.

2016


Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase.
Aeby E, Ahmed W, Redon S, Simanis V, Lingner J.
Cell Rep. 2016 Dec 20;17(12):3107-3114. doi: 10.1016/j.celrep.2016.11.071.

Transcription factor proteomics – tools, applications, and challenges.
Simicevic J, Deplancke B.
Proteomics. 2016 Nov 18. doi: 10.1002/pmic.201600317. [Epub ahead of print]

Primary Human and Rat Beta Cells Release the Intracellular Autoantigens GAD65, IA-2 and Proinsulin in Exosomes Together with Cytokine-Induced Enhancers of Immunity.
Cianciaruso C, Phelps EA, Pasquier M, Hamelin R , Demurtas D, Ahmed MA, Piemonti L, Hirosue S, Swartz MA, De Palma M, Hubbell JA, Baekkeskov S.
Diabetes. 2016 Nov 21. pii: db160671. [Epub ahead of print]

Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint.
Rudinskiy N, Fuerer C, Demurtas D, Zamorano S, De Piano C, Herrmann AG, Spires-jones TL, Oeckl P, Otto M, Frosch MP, Moniatte M , Hyman, BT, Schmid, AW
Alzheimers Dement. 2016 Sep;12(9):996-1013. doi: 10.1016/j.jalz.2016.03.011. Epub 2016 Apr 26.

A comparison of orbitally-shaken and stirred-tank bioreactors: pH modulation and bioreactor type affect CHO cell growth and protein glycosylation.
Monteil DT, Juvet V, Paz J , Moniatte M , Baldi L, Hacker DL, Wurm FM.
Biotechnol Prog. 2016 Sep;32(5):1174-1180. doi: 10.1002/btpr.2328. Epub 2016 Aug 11.

Quantitative telomeric chromatin isolation protocol for human cells.
Majerská J, Redon S, Lingner J.
Methods. 2016 Aug 9. pii: S1046-2023(16)30249-3. doi: 10.1016/j.ymeth.2016.08.003. [Epub ahead of print]

Extension of least squares spectral resolution algorithm to high-resolution lipidomics data.
Zeng YX, Mjøs SA, David FP, Schmid AW .
Anal Chim Acta. 2016 Mar 31;914:35-46. doi: 10.1016/j.aca.2016.02.002. Epub 2016 Feb 19.

2015


A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics.
Sadanandam A, Wullschleger S, Lyssiotis CA, Grötzinger C, Barbi S, Bersani S, Körner J, Wafy I, Mafficini A, Lawlor RT, Simbolo M, Asara JM, Bläker H, Cantley LC, Wiedenmann B, Scarpa A, Hanahan D.
Cancer Discov. 2015 Dec;5(12):1296-313. doi: 10.1158/2159-8290.CD-15-0068. Epub 2015 Oct 7.

Malaria Parasite-Infected Erythrocytes Secrete PfCK1, the Plasmodium Homologue of the Pleiotropic Protein Kinase Casein Kinase 1.
Dorin-Semblat D, Demarta-Gatsi C, Hamelin R , Armand F , Carvalho TG, Moniatte M , Doerig C.
PLoS One. 2015 Dec 2;10(12):e0139591. doi: 10.1371/journal.pone.0139591. eCollection 2015.

Flagellar membranes are rich in raft-forming phospholipids
Serricchio M, Schmid AW , Steinmann ME, Sigel E, Rauch M, Julkowska D, Bonnefoy S, Fort C, Bastin P, Bütikofer P.
Biol Open. 2015 Aug 14;4(9):1143-53. doi: 10.1242/bio.011957.

SwissPalm: Protein Palmitoylation database
Blanc M, David F, Abrami L, Migliozzi D, Armand F , Bürgi J, Gisou van der Goot F.
F1000Research 2015 Jul, 4:261

Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.
Matz A1, Halamoda-Kenzaoui B, Hamelin R , Mosser S, Alattia JR, Dimitrov M, Moniatte M , Fraering PC.
J Neurochem. 2015 May;133(3):409-21. doi: 10.1111/jnc.12996. Epub 2015 Feb 24.

Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson’s Disease via Protein Semisynthesis and Mutagenesis.
Burai R, Ait-Bouziad N, Chiki A, Lashuel HA.
J Am Chem Soc. 2015 Apr 22;137(15):5041-52. doi: 10.1021/ja5131726. Epub 2015 Apr 8.

An interplay between the p38 MAPK pathway and AUBPs regulate c-fos mRNA stability during mitogenic stimulation
Degese MS, Tanos T, Naipauer J, Gingerich T, Chiappe D , Echeverria P, LaMarre J, Gutkind JS, Coso OA.
Biochem J. 2015 Apr 1;467(1):77-90. doi: 10.1042/BJ20141100.

A mammalian transcription factor-specific peptide repository for targeted proteomics
Simicevic J, Moniatte M , Hamelin R , Ahrné E, Deplancke B.
Proteomics. 2015 Feb;15(4):752-6

 

2014


Anticytolytic screen identifies inhibitors of mycobacterial virulence protein secretion
Rybniker J, Chen JM, Sala C, Hartkoorn RC, Vocat A, Benjak A, Boy-Röttger S, Zhang M, Székely R, Greff Z, Orfi L, Szabadkai I, Pató J, Kéri G, Cole ST.
Cell Host Microbe. 2014 Oct 8;16(4):538-48. doi: 10.1016/j.chom.2014.09.008.

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function
Ryu D, Jo YS, Lo Sasso G, Stein S, Zhang H, Perino A, Lee JU, Zeviani M, Romand R, Hottiger MO, Schoonjans K, Auwerx J.
Cell Metab. 2014 Nov 4;20(5):856-69. doi: 10.1016/j.cmet.2014.08.001. Epub 2014 Sep 4.

The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain
Mosser S, Alattia JR, Dimitrov M, Matz A, Pascual J, Schneider BL, Fraering PC.
Hum Mol Genet. 2014 Sep 1. pii: ddu449. [Epub ahead of print]

Characterization of the surfaceome of the metal-reducing bacterium Desulfotomaculum reducens
Dalla Vecchia E, Shao PP, Suvorova E, Chiappe D , Hamelin R , Bernier-Latmani R.
Front Microbiol. 2014 Aug 19;5:432

Quantitative proteomics reveals the link between minichromosome maintenance complex and glucose-induced proliferation of rat pancreatic INS-1E β-cells
Schvartz D, Couté Y, Sanchez JC
J Proteomics. 2014 Aug 28;108:163-70.

Quantitative Mass Spectrometry Reveals Plasticity of Metabolic Networks in Mycobacterium smegmatis
Chopra T, Hamelin R , Armand F , Chiappe D , Moniatte M , McKinney JD
Mol Cell Proteomics. 2014 Nov;13(11):3014-28. doi: 10.1074/mcp.M113.034082. Epub 2014 Jul 5.

Nodal·Gdf1 Heterodimers with Bound Pro Domains Enable Serum-Independent Nodal Signaling and Endoderm Differentiation
Fuerer C, Nostro MC, Constam DB
J Biol Chem. 2014 Jun 20;289(25):17854-71.

c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson’s disease
Mahul-Mellier AL, Fauvet B, Gysbers A, Dikiy I, Oueslati A, Georgeon S, Lamontanara AJ, Bisquertt A, Eliezer D, Masliah E, Halliday G, Hantschel O, Lashuel HA
Hum Mol Genet. 2014 Jun 1;23(11):2858-79. doi: 10.1093/hmg/ddt674. Epub 2014 Jan 9.

The cysteine desulfurase IscS of Mycobacterium tuberculosis is involved in iron-sulfur cluster biogenesis and oxidative stress defense.
Rybniker J, Pojer F, Marienhagen J, Kolly GS, Chen JM, van Gumpel E, Hartmann P, Cole ST.
Biochem. J. (2014) Immediate Publication, doi:10.1042/BJ20130732

Genetic engineering of cell lines using lentiviral vectors to achieve antibody secretion following encapsulated implantation
Lathuilière A, Bohrmann B, Kopetzki E, Schweitzer C, Jacobsen H, Moniatte M , Aebischer P, Schneider BL
Biomaterials 2014 Jan, 35(2) 792–802

2013


A quantitative telomeric chromatin isolation protocol identifies different telomeric states
Grolimund L, Aeby E, Hamelin R , Armand F , Chiappe D , Moniatte M , Lingner J.
Nat Commun 2013 Nov 25;4:2848. doi: 10.1038/ncomms3848.

Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains.
Sha F, Gencer EB, Georgeon S, Koide A, Yasui N, Koide S, Hantschel O.
Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14924-9

Alpha-synuclein post-translational modifications as potential biomarkers for Parkinson’s disease and other synucleinopathies.
Schmid AW , Fauvet B, Moniatte M , Lashuel HA.
Mol Cell Proteomics. 2013 Aug 23. [Epub ahead of print]

Alzheimer’s disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production.
Dimitrov M, Alattia JR, Lemmin T, Lehal R, Fligier A, Houacine J, Hussain I, Radtke F, Dal Peraro M, Beher D, Fraering PC.
Nat Commun. 2013 Aug 2;4:2246. doi: 10.1038/ncomms3246.

Highly efficient production of the Alzheimer’s γ-secretase integral membrane protease complex by a multi-gene stable integration approach
Alattia J-R, Matasci M, Dimitrov M, Aeschbach L, Balasubramanian S, Hacker D.L, Wurm F.M, and Fraering P.C
Biotechnol Bioeng. 2013 Jul;110(7):1995-2005. doi: 10.1002/bit.24851. Epub 2013 Feb 15.

Absolute quantification of transcription factors during cellular differentiation using multiplexed targeted proteomics.
Simicevic J, Schmid AW , Gilardoni PA, Zoller B, Raghav SK, Krier I, Gubelmann C, Lisacek F, Naef F, Moniatte M , Deplancke B.
Nat Methods. 2013 Jun;10(6):570-6. doi: 10.1038/nmeth.2441.

Human adenovirus sunlight and UVC inactivation mechanisms as examined by qPCR and quantitative proteomics.
Bosshard F, Armand F , Hamelin R , Kohn T.
Appl Environ Microbiol. 2013 Feb;79(4):1325-32. doi: 10.1128/AEM.03457-12. Epub 2012 Dec 14.

Surface charge of polymer coated SPIONs influences the serum protein adsorption, colloidal stability and subsequent cell interaction in vitro
Hirsch V, Kinnear C, Moniatte M , Rothen B, Clift MJD, Fink AS
Nanoscale. 2013, Jan 18.

2012


Virus Inactivation Mechanisms: Impact of Disinfectants on Virus Function and Structural Integrity
Wigginton KR, Pecson BM, Sigstam T, Bosshard F, Kohn T.
Environ. Sci. Technol., 2012, 46(21): 12069-12078

Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: leucine 46 hydrophobic pocket.
El-Turk F, Fauvet B, Ashrafi A, Ouertatani-Sakouhi H, Cho MK, Neri M, Cascella M, Rothlisberger U, Pojer F, Zweckstetter M, Lashuel H.
PLoS One. 2012;7(9):e45024

Phosphorylation of α-Synuclein at Y125 and S129 Alters Its Metal Binding Properties: Implications for Understanding the Role of α-Synuclein in the Pathogenesis of Parkinson’s Disease and Related Disorders.
Lu Y, Prudent M, Fauvet B, Lashuel HA, Girault HH.
ACS Chem Neurosci. 2011 Nov 16;2(11):667-75

Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein
Fauvet B, Fares MB, Samuel F, Dikiy I, Tandon A, Eliezer D, Lashuel HA.
J Biol Chem. 2012 Aug 17;287(34):28243-62

Improved characterization of the insulin secretory granule proteomes.
Schvartz D, Brunner Y, Couté Y, Foti M, Wollheim CB, Sanchez JC.
J Proteomics. 2012 Aug 3;75(15):4620-31

Elucidating the Role of C-Terminal Post-Translational Modifications Using Protein Semisynthesis Strategies: α-Synuclein Phosphorylation at Tyrosine 125.
Hejjaoui M, Butterfield S, Fauvet B, Vercruysse F, Cui J, Dikiy I, Prudent M, Olschewski D, Zhang Y, Eliezer D, Lashuel HA.
J Am Chem Soc 2012  Mar 21:134(11):5196-210

Alpha-synuclein in the central nervous system and from erythrocytes, mammalian cells and E. coli exists predominantly as a disordered monomer.
Fauvet B, Kamdem MM, Fares MB, Desobry C, Michael S, Ardah MT, Tsika E, Coune P, Prudent M, Lion N, Eliezer D, Moore DJ, Schneider B, Aebischer P, El-Agnaf OM, Masliah E, Lashuel HA.
J Biol Chem 2012 May 4;287(19):15345-64

Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway.
Dastidar EG, Dayer G, Holland ZM, Dorin-Semblat D, Claes A, Chene A, Sharma A, Hamelin R , Moniatte M , Lopez-Rubio JJ, Scherf A, Doerig C.
BMC Biol. 2012  Jan 31; 10(1):5

2011


Interactions between cancer stem cells and their niche govern metastatic colonization.
Malanchi I, Santamaria-Martínez A, Susanto E, Peng H, Lehr HA, Delaloye JF, Huelsken J.
Nature. 2011 Dec 7;481(7379):85-9. doi: 10.1038/nature10694.

Mercury is a direct and potent [gamma]-secretase inhibitor affecting Notch processing and development in Drosophila.
Alattia JR, Kuraishi T, Dimitrov M, Chang I, Lemaitre B, Fraering PC.
FASEB J. 2011  Jul;25(7):2287-95.

Activation of a PAK-MEK signalling pathway in malaria parasite-infected erythrocytes
Sicard A, Semblat J-P, Doerig Ca, Hamelin R , Moniatte M , Dorin-Semblat D, Spicer J A, Srivastava A, Retzlaff S, Heussler V, Waters A P and Doerig Ch.
Cell Microbiol. 2011 Jun;13(6):836-45. doi: 10.1111/j.1462-5822.2011.01582.x.

Physiological adaptation of Desulfitobacterium hafniense strain TCE1 to tetrachloroethene respiration.
Prat L, Maillard J, Grimaud R, Holliger C.
Appl Environ Microbiol. 2011 Jun;77(11):3853-9.

PP2A phosphatase acts upon SAS-5 to ensure centriole formation in C. elegans embryos.
Kitagawa D, Flückiger I, Polanowska J, Keller D, Reboul J, Gönczy P.
Dev Cell. 2011 Apr 19; 20(4):550-62

Role of proteins in controlling selenium nanoparticle size.
Dobias J, Suvorova EI, Bernier-Latmani.
R. Nanotechnology. 2011 May 13;22(19):195605.

Tissue transglutaminase mediated glutamine deamidation of beta-amyloid peptide increases peptide solubility, whereas enzymatic cross-linking and peptide fragmentation may serve as molecular triggers for rapid peptide aggregation.
Schmid AW , Condemi E, Tuchscherer G, Chiappe D , Mutter M, Vogel H, Moniatte M , Tsybin YO.
J Biol Chem. 2011 Apr 8;286(14):12172-88.

Structural basis of the 9-fold symmetry of centrioles.
Kitagawa D, Vakonakis I, Olieric N, Hilbert M, Keller D, Olieric V, Bortfeld M, Erat MC, Flückiger I, Gönczy P, Steinmetz MO.
Cell. 2011 Feb 4;144(3):364-75.

2010


Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action.
Ouertatani-Sakouhi H , El-Turk F , Fauvet B , Cho MK , Pinar Karpinar D , Le Roy D , Dewor M , Roger T , Bernhagen J , Calandra T , Zweckstetter M , Lashuel HA .
J Biol Chem. 2010 Aug 20;285(34):26581-98.

Oxidation of virus proteins during UV(254) and singlet oxygen mediated inactivation.
Rule Wigginton K , Menin L , Montoya JP , Kohn T .
Environ Sci Technol. 2010 Jul 15;44(14):5437-43.

Evolution of S-cysteinylated and S-glutathionylated thiol precursors during oxidation of Melon B. and Sauvignon blanc musts.
Roland A , Vialaret J , Razungles A , Rigou P , Schneider R
J Agric Food Chem. 2010 Apr 14;58(7):4406-13.

Binding of silver nanoparticles to bacterial proteins depends on surface modifications and inhibits enzymatic activity.
Wigginton NS, de Titta A, Piccapietra F, Dobias J, Nesatyy VJ, Suter MJ, Bernier-Latmani R
Environ Sci Technol. 2010 Mar 15;44(6):2163-8.

Validation of a nanoliquid chromatography-tandem mass spectrometry method for the identification and the accurate quantification by isotopic dilution of glutathionylated and cysteinylated precursors of 3-mercaptohexan-1-ol and 4-mercapto-4-methylpentan-2-one in white grape juices.
Roland A , Vialaret J , Moniatte M , Rigou P , Razungles A , Schneider R .
J Chromatogr A. 2010 Mar 5;1217(10):1626-35

Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.
Paleologou KE , Oueslati A , Shakked G , Rospigliosi CC , Kim HY , Lamberto GR , Fernandez CO , Schmid A , Chegini F , Gai WP , Chiappe D , Moniatte M , Schneider BL , Aebischer P , Eliezer D , Zweckstetter M , Masliah E , Lashuel HA .
J Neurosci. 2010 Mar 3;30(9):3184-98.

Phosphorylation of synucleins by members of the Polo-like kinase family.
Mbefo MK , Paleologou KE , Boucharaba A , Oueslati A , Schell H , Fournier M , Olschewski D , Yin G , Zweckstetter M , Masliah E , Kahle PJ , Hirling H , Lashuel HA .
J Biol Chem. 2010 Jan 22;285(4):2807-22.

2009


Phosphorylation of SAS-6 by ZYG-1 is critical for centriole formation in C. elegans embryos.
Kitagawa D , Busso C , Flückiger I , Gönczy P .
Dev Cell. 2009 Dec;17(6):900-7.

Dissecting the mechanisms of tissue transglutaminase-induced cross-linking of alpha-synuclein: implications for the pathogenesis of Parkinson disease.
Schmid AW , Chiappe D , Pignat V , Grimminger V , Hang I , Moniatte M , Lashuel HA .
J Biol Chem. 2009 May 8;284(19):13128-42.

Electron capture and transfer dissociation: Peptide structure analysis at different ion internal energy levels.
Ben Hamidane H , Chiappe D , Hartmer R , Vorobyev A , Moniatte M , Tsybin YO .
J Am Soc Mass Spectrom. 2009 Apr;20(4):567-75.

2008


Regulation of glutamate metabolism by protein kinases in mycobacteria.
O’Hare HM , Durán R , Cerveñansky C , Bellinzoni M , Wehenkel AM , Pritsch O , Obal G , Baumgartner J , Vialaret J , Johnsson K , Alzari PM .
Mol Microbiol. 2008 Dec;70(6):1408-23.